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Apigenin

Flavone from chamomile that promotes deep sleep and lowers estrogen aromatization.

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Primary benefits

  • Promotes deep sleep
  • Calming
  • May lower aromatase

How to take it

Dosing range

50–100 mg

Timing

before bed

Interactions & contraindications

Avoid if:

  • · Pregnancy

Drug interactions:

  • · CYP3A4 substrates
  • · Sedatives

Always consult a healthcare provider before starting any new supplement, especially if you take prescription medications.

Research citations

  1. [1]Apigenin: a promising molecule for cancer prevention

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Why Apigenin Beats Melatonin for Most Adults

While melatonin dominates the sleep supplement market, emerging evidence suggests apigenin offers comparable sleep benefits with fewer disruptions to natural circadian rhythms and better long-term tolerance.

Dr. Sarah ChenApr 23, 2026